Well, my OSCON proposal about scripting Mac OS X applications was accepted. Coincidentally, just yesterday I wrote a long piece about the discoveries I had made over the past year that would improve gensuitemodule to the MacPython mailing list. I think the ball is really going to start rolling this year. A lot more people are interested in Python, Mac OS X, and scripting, and Python has huge untapped potential in this area. I think the lack of documentation of the Python AppleEvent modules along with the generally arcane AppleEvent architecture prevented all but the most daring (me) from even attempting to do anything.
Good things are afoot.